Helps combat exerciseinduced inflammation and decreases measures of muscle damage and soreness
In the recently published study, a visual analog scale was used to obtain the subjects’ perception of muscle soreness at two and 48 hours
post exercise, with less muscle soreness suggesting better exercise recovery. There were statistically significant increases in muscle soreness with and
without product two hours post exercise (p=0.021 and p=0.007 respectively) supporting the fact that the exercise protocol was of sufficient intensity to induce
soreness. It was found that the low-dose group (1.5 grams) had an 0.5 point greater reduction in muscle soreness after supplementation with MSM than baseline,
and the high-dose group (3.0 grams) had a 1 .5 point greater reduction in soreness after supplementation compared to baseline. This 1.0 point difference between
dosages in baseline-adjusted muscle soreness from two hours post exercise to 48 hours post exercise
approached statistical significance suggesting a product dose related improvement. In the study titled “Effect of methylsulfonylmethane supplementation on exercise induced muscle damage and total antioxidant capacity”
The enzyme creatine kinase (CK) was measured. Elevated CK is indicative of trauma or skeletal muscle damage. This kind of damage or
trauma would generally cause an inflammatory response and pain. Significantly lower values of CK were found in the MSM group compared to placebo at 24 and 48 hours post exercise. These results suggest that MSM may protect the muscles from damage from acute bouts of exercise and the resulting soreness or inflammation that may accompany it.
Reduces oxidative stress following exercise The published study by Nakostin-Roohi et al. (2011 )3 showed a decrease in oxidated glutathione and an
increase in reduced glutathione compared to placebo following an acute bout of exercise. This suggests a reduction in oxidative stress. These results are
consistent with results from an equine model used by Marafion et al (2008). Oxidative stress is caused by an imbalance between the production of reactive oxygen
and nitrogen species (RONS) and the body’s natural ability to neutralize these radicals. This can lead to oxidative damage of cells. Measurements of specific
marker compounds can be used to determine the degree of cellular damage and their components such as lipids, proteins and DNA. Malondialdehyde (MDA) is a naturally occurring product of lipid peroxidation. MDA was evaluated by Kim2 and Nakhostin-Roohi3 with significant decreases seen by both for the MSM
treatment group vs. placebo.